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Download e-book for iPad: A Handbook for DNA-Encoded Chemistry: Theory and by Robert A. Goodnow Jr.

By Robert A. Goodnow Jr.

This publication comprehensively describes the advance and perform of DNA-encoded library synthesis know-how. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of present hit new release applied sciences resembling high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a beneficial advisor for realizing and utilizing DNA-encoded combinatorial chemistry
  • Helps chemists generate and display novel chemical libraries of huge dimension and caliber
  • Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – man made and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists easy methods to successfully increase on hand “chemical house” for drug discovery
  • Provides specialist and updated precis of pronounced literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Additional info for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

Sample text

A. Houghten Additional enhancement of process efficiency for peptide synthesis 6. 1992 Solid-phase synthesis J. A. Ellman Clear demonstration of of benzodiazepines the potential for pharmaceutical smallmolecule research 7. 1988–1991 Split-and-pool A. Furka Theoretical basis to create large numbers of compounds 8. 1992 Encoding with DNA S. Brenner and Concept experiment for R. A. Lerner using DNA to encode small-molecule synthesis 9. 1993 Encoding split-and- M. A. Gallop Synthesis and encoding of pool libraries with approximately one DNA million peptides with DNA-based encoding 10.

Moran encoding method for solid-phase synthesis 12. 1995 Materials science P. Schultz et al. Spatially addressable applications combinatorial libraries of copper oxide films for superconducting materials research Ref.  (cont'd). # Year Notable discovery or advance 13. 1996 Catalyst development with high-throughput methods 14. 1998 High-throughput purification 15. 2000 DOS concept 16. 2008 Development of cheap high-throughput sequencing technology Report of first 800 million DNA-encoded compound library 17.

Natl. Acad. Sci. , 74, 560–564. 21. , Coulson, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. , 74, 5463–5467. 22. , Ji, H. (2008). Next-generation DNA sequencing. Nat. , 26, 1135–1145. 23. Fuller, C. , Middendorf, L. , Benner, S. , Church, G. , Jovanovich, S. , Nelson, J. , Schloss, J. , Schwartz, D. , Vezenov, D. V. (2009). The challenges of sequencing by synthesis. Nat. , 27, 1013–1023. 24. Metzker, M. L. (2010). Sequencing technologies—the next generation.

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