Download e-book for kindle: Analogue-based Drug Discovery by Janos Fischer, C. Robin Ganellin, David P. Rotella

By Janos Fischer, C. Robin Ganellin, David P. Rotella

The 1st authoritative assessment of earlier and present concepts for profitable drug improvement by means of analog new release, this special source spans all very important drug periods and all significant healing fields, together with histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.Of the nineteen analog periods offered intimately, nine are defined by means of the scientists who discoverd them.The e-book encompasses a desk of the main profitable drug analogs as in line with the IMS score and compares them when it comes to chemical constitution, mode of motion and patentability.

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Cyclization to the morpholine yields the antidepressant viloxazine (mode 1), whereas cyclization to chromanols (mode 2) yields the potassium channel blocker cromakalim. O O 1 OH O NH O 1 H N viloxazine O O 2 2 OH NC OH N HN O cromakalim Fig. 9 Two modes of cyclization of the side chain in b-blockers yield the noradrenaline (NA) reuptake inhibitor viloxazine (mode 1) and the potassium channel blocker cromakalim (mode 2). 7 Twin Drugs The search for cationic cholinergic agents has led to numerous twin drugs (Fig.

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