Analogue-based Drug Discovery III - download pdf or read online

By Janos Fischer, C. Robin Ganellin, David P. Rotella

So much medicines are analogue medicinal drugs. There aren't any normal ideas how a brand new drug could be came across, however, there are a few observations which aid to discover a brand new drug, and likewise someone tale of a drug discovery can start up and support new discoveries. quantity III is a continuation of the winning publication sequence with new examples of validated and lately brought medicinal drugs.
The significant a part of the booklet is written through key inventors both as a case research or a research of an analogue classification. With its wide variety throughout numerous healing fields and chemical periods, this can be of curiosity to nearly each researcher in drug discovery and pharmaceutical chemistry, and -- including the former volumes -- constitutes the 1st systematic method of drug analogue improvement.

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2002) Structure-based design of novel potent nonpeptide thrombin inhibitors. J. Med. , 45, 1757–1766. W. I. (2010) Update on antithrombotic therapy. New anticoagulants. Circulation, 121, 1523–1532. W. S. (1962) Pharmacology of a new adrenergic betareceptor-blocking compound. Lancet, 2 (7251), 311–314. C. (1964) A new adrenergic beta-receptor antagonist. Lancet, 1 (7342), 1080–1081. , and Le Count, D. (1973) A new type of cardioselective adrenoceptive blocking drug. Br. J. , 48, 3408. , and Friderichs, E.

Bioorg. Med. Chem. , 20, 453–457. , and Kunos, G. (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J. Clin. , 120, 2953–2966. D. in Computational Chemistry in 2003 from the University of London. He joined the Computational Sciences section of Pharmacia (Pfizer Group, Nerviano, Italy) in 2002, and then moved to the Medicinal Chemistry Department of AstraZeneca (M€ olndal, Sweden) in 2004, where he is currently working as Principal Scientist in addition to his role as Project Leader in Drug Discovery.

R. (2006) Development of antiulcer H2-receptor histamine antagonists, in Analogue-Based Drug Discovery (eds J. R. Ganellin), Wiley-VCH Verlag GmbH, Weinheim, pp. 71–80. S. (1972) Inhibition of converting enzyme by venom peptides, in Hypertension (eds J. Genest and E. Koiw), Springer, Berlin, pp. 541–547. W. (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science, 196, 441–444. A. (1980) A new class of angiotensinconverting enzyme inhibitors.

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