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Extra resources for Antioxidants - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Generate_Screen • Project Title: MITOCHONDRIAL NEURODEGENERATION OXIDATIVE STRESS AND Principal Investigator & Institution: Melov, Simon; Assistant Professor; Buck Institute for Age Research Novato, Ca 94945 Timing: Fiscal Year 2001; Project Start 15-AUG-2000; Project End 31-JUL-2005 Summary: (Verbatim from the Applicant's Abstract) Oxidative stress has been hypothesized to be a major factor in the etiology of many progressive age related neurodegenerative diseases including Alzheimer and Parkinson disease, amytrophic lateral sclerosis, Friedreichs ataxia, and the prion diseases.
Professor; Brigham and Women's Hospital 75 Francis Street Boston, Ma 02115 Timing: Fiscal Year 2003; Project Start 17-APR-1992; Project End 31-JUL-2008 Summary: (provided by applicant): This New England-based case-control study has sought to identify risk factors for ovarian cancer mediated through depletion of ovarian germ cells and gonadotropin excess. New theories with a molecular basis and considering roles for ovarian steroids, inflammation, and certain genetic polymorphisms now need to be incorporated.
The specific aims are 1) Characterize the metabolism of the affected areas of the brain to determine if there is a metabolic differential relative to unaffected areas; 2) Determine whether cell loss contributes to the progression of the spongiform changes; 3) Characterize at the biochemical and enzymatic level the changes due to mitochondrial oxidative stress within the brain and the efficacy of various synthetic antioxidants in attenuating such changes; 4) Investigate gene expression changes in the brain in relation to endogenous mitochondrial oxidative stress via microarray analysis.